Hemoglobinopathy Fractionation Profile w/Solubility
Fasting Required: No

Specimen: Blood

Lab: Quest Diagnostics

Results: 3-5 business days
Note: Result turnaround times are an estimate and are not guaranteed. Our reference lab may need additional time due to weather, holidays, confirmation/repeat testing, or equipment maintenance.

Special Instructions: SOLUBILITY TESTING should never be utilized as a primary screening tool.

Includes: Hemoglobin A1, Fetal Hemoglobin, Hemoglobin A2 and any hemoglobin variants, Red Blood Cell Count, Hemoglobin, Hematocrit, MCV, MCH, RDW

Description: The Hemoglobinopathy Fractionation Profile Blood Test, or Hemoglobin Fractionation, aids in the diagnosis of hemoglobinopathy, an inherited blood disorder characterized by the presence of an abnormal form of hemoglobin (known as a variant) or decreased hemoglobin production (known as thalassemia). Hemoglobin (Hb) is a protein found in red blood cells (RBCs) that binds to oxygen and helps transport it throughout the body. The shape, size and function of RBCs may be altered when hemoglobin variants are present, which could result in inefficient oxygen transportation and premature destruction of the cells, leading to hemolytic anemia. Symptoms of hemolytic anemia include weakness, fatigue, jaundice and pale skin. Severe hemoglobinopathies, such as homozygous Hb S (Sickle Cell Anemia), can result in symptoms such as episodes of acute pain, shortness of breath and an enlarged spleen.

Hemoglobin Fractionation quantifies (in relative percentages) the normal forms of hemoglobin present, including A, A2 and F, as well as the variants S and C.

Most hemoglobins are soluble but hemoglobin S is not. The solubility test should only be used as a screening test as it is not reliable for diagnosing sickle cell disease.

Alternative Name(s): Hemoglobin Electrophoresis, HGB Variants, HB S, Hemoglobin F, HGB Evaluation, Hemoglobin S, HB A2, HGB Electrophoresis, Hemoglobin Variants, Hemoglobin A2, Thalassemia Screen, HB F