Estradiol (E2) Hormone
Fasting Required: No

Specimen: Blood

Results: 3-5 Business Days
Note: Result turnaround times are an estimate and are not guaranteed. Our reference lab may need additional time due to weather, holidays, confirmation/repeat testing, or equipment maintenance.

Collection Instructions:
Note: For any patients for whom low estradiol levels are anticipated (e.g. males, pre-pubertal children and hypo-gonadal/post-menopausal females), the Quest Diagnostics Estradiol, Ultra sensitive, LC/MS/MS assay is recommended (test code 30289).

Description: Estradiol, also known as E2, is the most active of the estrogens. For women, it is important to look at the relationship between estradiol and progesterone in evaluating menopausal symptoms such as hot flashes, mood disorders, and aging skin. In men, high levels of estradiol are associated with abdominal fat, enlargement of the prostate and cardiovascular risk. In both men and women, low levels of estradiol are associated with osteoporosis.

Measuring the circulating levels of estradiol is important for assessing the ovarian function and monitoring follicular development for assisted reproduction protocols. Estradiol plays an essential role throughout the human menstrual cycle. Elevated estradiol levels in females may also result from primary or secondary ovarian hyperfunction. Very high estradiol levels are found during the induction of ovulation for assisted reproduction therapy or in pregnancy. Decreased estradiol levels in females may result from either lack of ovarian synthesis (primary ovarian hypofunction and menopause) or a lesion in the hypothalamus-pituitary axis (secondary ovarian hypofunction). Elevated estradiol levels in males may be due to increased aromatization of androgens, resulting in gynecomastia.