Methylation Profile-Doctor's Data Kit

Note: This is a test kit that will be mailed to you. It requires a blood draw. It is your responsibility to arrange the blood draw for your kit and payment of your specimen collection.

Fasting Required: Yes - Overnight

Specimen: Blood

Results: 7-10 Business Days

Special Instructions: 48 hours prior to the specimen collection discontinue taking dietary supplements containing methionine, cysteine, and SAMe unless otherwise directed by your physician.

The samples must be received at the lab within 7 days after removing from the freezer

Description: Methylation is a process by which a gene's behavior is altered, but the gene itself isn't changed. It requires Vitamin B12 and Folic Acid to convert nutrients from food to energy. If the process is blocked, through stress, viruses, toxins, etc., Glutathione cannot be created. Glutathione detoxifies the body, among other body processes.

Normal methionine metabolism is absolutely critical for folate-dependent transmethylation, and transsulfuration. Abnormal metabolism of methionine can be found in both genders at any age. It is usually associated with genetic or nutritional deficiencies, aging and exposures to environmental toxins. For example, lead can impair methylation via inhibition of the enzyme methylenetetrahydrofolate reductase (MTHFR).

Conditions associated with untreated, aberrant methionine metabolism include, but are not limited to:

The DDI Methylation profile evaluates the plasma levels of methionine, cysteine, SAM, SAH, Hcy and cystathionine, and provides the important "methylation index," a ratio of SAM to SAH. The test results can appropriately guide nutritional support to improve or normalize methionine metabolism and meliorate or prevent the potential adverse consequences associated with inadequate methylation and transsulfuration capacity.

Analytes Reported:
Cystathionine, plasma
Cysteine, plasma
Homocysteine, plasma
Methionine, plasma
S-adenosylhomocysteine; plasma
S-adenosylmethionine; plasma
SAM, SAH ratio

Note: Result turnaround times are an estimate and are not guaranteed. Our reference lab may need additional time due to weather, holidays, confirmation/repeat testing, or equipment maintenance.