Gliadin Antibody Profile (IgG, IgA)
Fasting Required: No

Specimen: Blood

Lab: Quest Diagnostics

Results: 1-2 business days

Note: Result turnaround times are an estimate and are not guaranteed. Our reference lab may need additional time due to weather, holidays, confirmation/repeat testing, or equipment maintenance.

Description: Gliadin is a class of proteins found in the gluten of wheat, rye, barley, and oats. This test is used to aid in the diagnosis and monitoring of certain gluten-sensitive enteropathies(diseases of the intestinal tract), such as celiac disease and dermatitis herpetiformis.

Limitations: Tissue transglutaminase (tTG;IgA) antibody is an excellent first-line marker, with high sensitivity and specificity in untreated individuals. The endomysial antibody (EMA;IgA) assay has high specificity for celiac disease and is used to confirm positive IgA anti-tTG results. Although this panel tests for EMA only when anti-tTG (IgA) results are positive, EMA testing can be ordered separately if the IgA anti-tTG result is negative but clinical suspicion remains high. Some patients with limited villous atrophy have been reported to lack EMA and tTG antibodies; testing for IgA antigliadin antibody (AGA) may help detect celiac disease in such patients. Total serum IgA is measured to identify selective IgA deficiency, present in about 2% to 10% of celiac disease patients. Such patients would have negative results on IgA anti-tTG and EMA assays but may have positive IgG anti-tTG results.

Alternative Name(s): Antigliadin Ab (IgA, IgG), Deamidated Gliadin (IgA, IgG), Anti-Gliadin Ab (IgA, IgG), Gliadin (IgA, IgG), DGP (IgA, IgG)